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Satellite Symposia

There will be five satellite symposia for this year’s conference, all taking place on Saturday, June 13th from 8:30 am until 3:20 pm. Participants must sign up for one symposium and pay an additional $75 fee to attend, and this includes refreshment breaks and lunch.

1. Shaping the Infected Cell Proteome
2. Frontiers in Invertebrate Virology
3. Co-transmission of Multiple Virus Genomes
4. Viral Evolution of Immune Evasion
5. Viral Modulation of Host Cell Metabolism

Note that you can freely move between the different symposia once they have started.  Please contact Conference Services if you have already registered for the conference and wish to add a Satellite Symposium after the fact.


1. Shaping the Infected Cell Proteome
Organizers:
    Felicia Goodrum, University of Arizona, Councilor for Animal Virology
    Scott Terhune, Medical College of Wisconsin

While no virus encodes its own protein synthesis machinery, viruses have evolved an array of mechanisms to ensure the synthesis of their proteins and shape the proteome of the infected cells for successful infection. Viruses have long been known to manipulate the host proteome by alteration of mRNA export from the nucleus, cleavage of translation initiation factors, and modulation of mTOR. However, we continue to learn how viruses expand their coding potential, increase protein diversity, and shape the host proteome through harnessing cellular stress pathways, use of alternative transcriptional and translational starts, selective turnover of proteins, and regulation of ribosomes. This symposium will bring together a diverse group of virologists and scientists outside virology to explore how viruses expand protein diversity and shape the infected cell proteome. 

  • Christopher Nicchitta – Regulating the Global Proteome by Spatial Organization of Translation During Stress and Infection
  • Scott Tibbetts – Complexity of g-Herpesvirus Gene Expression
  • Felicia Goodrum – Protein Isoforms and Their Differential Roles in Regulating Latency and Reactivation
  • Luwanika Mlera – Protein Isoforms and Their Differential Roles in Regulating Latency and Reactivation
  • Sunnie Thompson – Non-canonical Mechanisms of Translation During Retrovirus Infection
  • Nat Moorman – Creating protein diversity with alternative 5’UTR’s during cytomegalovirus infection
  • Ian Mohr – Remodeling Translational Machinery During Virus Infection
  • Andrew Mehle – Regulation of the Influenza RNA Polymerase
  • Noam Stern-Ginossar – Uncovering Viral Protein Diversity at the Ribosome
  • Priya Shah – Comparative mapping of flavivirus-host protein interaction networks
  • Scott Terhune – Dynamics of Viral-host Protein Interaction Networks During Cytomegalovirus Infection

2. Frontiers in Invertebrate Virology
Organizers:
    Paul Friesen, University of Wisconsin-Madison, Councilor for Invertebrate Virology
    Lorena Passarelli, Kansas State University
    Gary Blissard, Cornell University
    Rollie Clem, Kansas State University
    David Theilmann, Agriculture and Agri-Food Canada

Advances in next generation sequencing and metagenomic analyses of invertebrates have uncovered an astonishing diversity of new insect viruses and previously recognized virus families in a complex relationship with their insect host. This satellite symposium will explore the most recent topics of invertebrate virus evolution, novel host-virus interactions, gene expression strategies of RNA and DNA viruses, insect anti-viral immunity, and arthropod transmission in an effort to cohesively examine these diverse discoveries as they relate to invertebrate pathology and insect immunity. 

  • Gorben Pijlman – Non-coding viral RNAs in flavivirus transmission by mosquitoes
  • Paul Ahlquist – Nodavirus RNA Replication Complex Architecture Reveals Mechanistic Insights into (+)RNA Virus Genome Replication
  • Gary Blissard – Exploring baculovirus-cell interactions and crosstalk through analysis of viral and host transcriptomes and targeted RNAi screens.
  • Michelle Flenniken – Honey Bee Viruses, Colony Health, and Antiviral Defense
  • Rollie Clem – The mosquito midgut barrier to arbovirus infection
  • Lorena Passarelli – Alternative pathways of disulfide bond formation used by invertebrate viruses
  • David Theilmann – TBA

3. Co-transmission of Multiple Virus Genomes
Organizers:
    Nihal Altan-Bonnet, National Institutes of Health
    Roberto Cattaneo, Mayo Clinic

Mechanisms that enable multiple animal viral genomes to be transported together, within and between hosts, have only recently gained attention. This symposium will review newly discovered processes that enveloped or non-enveloped viruses exploit to allow multiple genomes to collectively penetrate individual cells, enhancing infectivity. 

  • Stephane Blanc – Co-transmission of Plant Virus Genomes
  • Andrea Erikson – Gut Bacteria Promote Co-infection, Recombination, and Reassortment of Enteric Viruses
  • Gustavo Palacios – Multicomponent Animal Viruses
  • Walter Mothes – Co-transmission of Retrovirus Genomes at Virological Synapses
  • Benjamin Chen – Genetic Diversity, Antibody Escape, and HIV Pathogenesis
  • Moriah Szpara – Lethal Perinatal Transmission of Diverse Herpes Simplex Virus Genomes
  • Anice Lowen – Complementation of Influenza Virus Genomes in vivo
  • Becky Dutch – Cell-to-cell “en bloc” Pneumovirus Transmission
  • Roberto Cattaneo – Measles Virus Quasispecies Adaptations to Airway Epithelia, Immune Cells, and Brain
  • Nihal Altan-Bonnet – Virus Genome Co-transmission through Extracellular Vesicles

4. Viral Evolution of Immune Evasion
Organizers:
    Alon Herschhorn, University of Minnesota
    James Munro, University of Massachusetts Medical School

This satellite will provide a comprehensive view on how viruses evolve to escape the immune response. The session is designed to follow a didactic sequence, starting with providing a strong basis on viral robustness and evolution, followed by specific examples of immune targeting, and eventually highlighting the pathways of immune evasion mediated by viral evolution. We will present topics related to evolution of different viruses in the context of escape from immune response and will link common aspects that are instrumental to understanding the objectives. The session will focus on basic science but will provide insights into related translational applications and highlight unmet medical needs. 

  • Alon Herschhorn – Introduction. Viral evolution – Immune response – Immune evasion.
  • Justin Meyer – TBA
  • Sara Sawyer – TBA
  • James Munro – Dynamics of the Ebola envelope glycoprotein during antibody-mediated neutralization
  • Leah Katzelnick – Antigenic cartography: mapping the antigenic evolution of RNA viruses to inform vaccine design
  • Zachary Bornholdt – The Discovery and Development of the pan-Ebolavirus Immunotherapeutic MBP134
  • Jesse Bloom – Mapping person-to-person variation in viral mutations that escape human immunity to influenza
  • Matthew Aliota – TBA
  • Julie Overbaugh – TBA

5. Viral Modulation of Host Cell Metabolism
Organizers:
    Christiane E. Wobus, University of Michigan
    John Purdy, University of Arizona

As obligate intracellular pathogens, viruses rely on metabolic products of host cells. To ensure availability of biomolecules and energy for replication, viruses hijack metabolic resources and stimulate specific metabolic pathways, becoming metabolic engineers. On the other hand, cells change their metabolic programs to mount effective defenses. Thus, studying metabolism during infection is critical for understanding not only virus-host interactions but also identifying novel therapeutic approaches. This symposium will explore how host metabolism supports or limits virus replication or the immune response to viral infection. It will bring together virologists from diverse fields who are studying or considering studying metabolism, highlight modern methods for performing metabolic experiments (such as functional assays, flux analysis, metabolomics and lipidomics), and provide a venue where new collaborations can be discussed to further research in this emerging field of virus-host interaction. 

  • John Connor – Filoviruses are addicted to polyamines and hypusinated eIF5A
  • Stacey Schultz-Cherry – Obesity + Flu; Not a Good Combination.
  • Vera Tarakanova – Chewing the fat: gammaherpesvirus infection and lipid metabolism.
  • John Purdy – Control of cell-to-cell spread of human cytomegalovirus by amino acid metabolism
  • Ruskia Perera – Flipping Metabolism: Controlling Flavivirus Transmission and Pathogenesis
  • Christiane E. Wobus – Diversity in the role of metabolism during norovirus infection
  • Micah Luftig – Metabolic regulation by Epstein-Barr virus as a key driver of B-cell immortalization
  • Peter Nagy – TBA
  • Naomi Taylor – TBA